
American Airlines Flights from Myrtle Beach (MYR) to San Diego (SAN)
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American Airlines Flights from MYR to SAN
How much is a American Airlines flight from Myrtle Beach (MYR) to San Diego (SAN)?
One-way flights start as little as and there are roundtrips available from . Get in! You can score some sweet deals with Wotif and American Airlines.
How many non-stop American Airlines flights from Myrtle Beach (MYR) to San Diego (SAN) are there per day?
American Airlines flies flights direct every day between Myrtle Beach (MYR) and San Diego (SAN).
How far is Myrtle Beach (MYR) from San Diego (SAN)?
It’s from Myrtle Beach (MYR) to San Diego (SAN).
What is the best airline to fly from Myrtle Beach Intl.?
At Wotif, we give you all the available options from our reputable partners. Select the airline that best suits your preferences and membership loyalties. You can fly from Myrtle Beach Intl. with: .
Can I change or cancel my American Airlines tickets from Myrtle Beach to San Diego on Wotif?
Change of plans? No worries! We’re right here to make things as easy as possible. Check out the American Airlines rules and restrictions in your itinerary. You can also use the No Change Fees filter to find flexible plane tickets for future trips. For more information on how to cancel or change your flight on Wotif, visit our customer service portal.
How do I find the best deal on American Airlines flights from Myrtle Beach (MYR) to San Diego (SAN)?
Just review and compare all our awesome offers or enter your travel dates to see more terrific deals on American Airlines flights from Myrtle Beach. And remember you can save even more when you bundle a hotel with your flight as part of a Wotif package. Sweet!
What’s a good way to get cheap American Airlines flight tickets from Myrtle Beach to San Diego?
We have loads of cheap flights, so just enter your travel dates to see what’s available. If you can be flexible on when you fly, you’ll find even more epic flight deals. So get booking!
What is the cheapest time of year to fly from Myrtle Beach (MYR) to San Diego (SAN)?
The cheapest time of the year for a return trip is . One-way, the cheapest month to fly is . Check our deal cards for details.
How long does it take to fly from MYR to SAN?
It typically takes hours to fly directly from Myrtle Beach (MYR) to San Diego (SAN).
Epic Hotel in San Diego

Sheraton San Diego Resort
Overall amazing
Reviewed on 22 Apr 2026

Wyndham San Diego Bayside
No breakfast options or even coffee, unless you go to a nearby restaurant. Dinner at a deli with homeless people hanging at the outdoor tables next to us. Very expensive for what you receive. Only positives: Good location--walking distance to port, and spacious, clean room.
Reviewed on 24 Apr 2026

Handlery Hotel
Beds were very uncomfortable plus the pillows were like small squares of pillow stuffing not comfortable at all. Our sliding glass door was very hard to open n shut. Besides that everything was okay.
Reviewed on 24 Apr 2026
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^Savings based on all package bookings made with Flight + Hotel on Wotif.co.nz from , as compared to the price of the same components booked separately. Savings will vary based on origin/destination, length of trip, stay dates and selected travel supplier(s). Savings not available on all packages.