American Airlines Flights from Knoxville (TYS) to San Diego (SAN)
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American Airlines Flights from TYS to SAN
How much is a American Airlines flight from Knoxville (TYS) to San Diego (SAN)?
One-way flights start as little as and there are roundtrips available from . Get in! You can score some sweet deals with Wotif and American Airlines.
How many non-stop American Airlines flights from Knoxville (TYS) to San Diego (SAN) are there per day?
American Airlines flies flights direct every day between Knoxville (TYS) and San Diego (SAN).
How far is Knoxville (TYS) from San Diego (SAN)?
It’s from Knoxville (TYS) to San Diego (SAN).
What is the best airline to fly from McGhee Tyson?
At Wotif, we give you all the available options from our reputable partners. Select the airline that best suits your preferences and membership loyalties. You can fly from McGhee Tyson with: .
Can I change or cancel my American Airlines tickets from Knoxville to San Diego on Wotif?
Change of plans? No worries! We’re right here to make things as easy as possible. Check out the American Airlines rules and restrictions in your itinerary. You can also use the No Change Fees filter to find flexible plane tickets for future trips. For more information on how to cancel or change your flight on Wotif, visit our customer service portal.
How do I find the best deal on American Airlines flights from Knoxville (TYS) to San Diego (SAN)?
Just review and compare all our awesome offers or enter your travel dates to see more terrific deals on American Airlines flights from Knoxville. And remember you can save even more when you bundle a hotel with your flight as part of a Wotif package. Sweet!
What’s a good way to get cheap American Airlines flight tickets from Knoxville to San Diego?
We have loads of cheap flights, so just enter your travel dates to see what’s available. If you can be flexible on when you fly, you’ll find even more epic flight deals. So get booking!
What is the cheapest time of year to fly from Knoxville (TYS) to San Diego (SAN)?
The cheapest time of the year for a return trip is . One-way, the cheapest month to fly is . Check our deal cards for details.
How long does it take to fly from TYS to SAN?
It typically takes hours to fly directly from Knoxville (TYS) to San Diego (SAN).
Epic Hotel in San Diego
Sheraton San Diego Resort
Loved it! So clean and hot tub was nice and hot!
Reviewed on 6 Apr 2026
Wyndham San Diego Bayside
We stayed here one night because we were cruising the next day out of the Port of San Diego. Hotel is older and showing its age a bit. Rooms are very large. Location is great for port and Embarcadero area.
Reviewed on 5 Apr 2026
Best Western Seven Seas
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^Savings based on all package bookings made with Flight + Hotel on Wotif.co.nz from , as compared to the price of the same components booked separately. Savings will vary based on origin/destination, length of trip, stay dates and selected travel supplier(s). Savings not available on all packages.